Huntington’s disease alters human neurodevelopment

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Dietary Alpha-Lipoic Acid Alters Piglet Neurodevelopment

INTRODUCTION Alpha-lipoic acid (a-LA) is an antioxidant shown to ameliorate age-associated impairments of brain and cardiovascular function. Human milk is known to have high antioxidant capacity; however, the role of antioxidants in the developing brain is largely uncharacterized. This exploratory study aimed to examine the dose-response effects of a-LA on piglet growth and neurodevelopment. ...

Huntingtin and the molecular pathogenesis of Huntingtons disease

Huntington’s disease (HD) is a late-onset neurodegenerative disorder that is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (htt). The normal function of htt, and the molecular mechanisms that contribute to the disease pathogenesis, are in the process of being elucidated. In this review...

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease

Alzheimer's Disease Neurodevelopment Converges with Neurodegeneration

dues, perhaps by a CNR-associated Src family protein Alzheimer’s disease (AD) is the most common senile tyrosine kinase. Phosphorylation of Dab somehow dementia in the elderly. The disease is characterized causes the migrating neuron to cease migrating, release behaviorally by global cognitive decline, and defined from its substratum, the radial glial cell, and begin to histologically by two di...